the effect of prebiotics on production of antimicrobial compounds from lactobacillus spp. against proteus mirabilis (atcc 7002 and ptcc 1076)

lactobacillus spp are a group of gram-positive, non-spore forming, cocci or rod shaped, catalase negative organisms that benefit to the host. prebiotics are non-digestible food ingredients that stimulate the growth and /or activity of bacteria in the digestive system in ways claimed to be beneficial to health. this study was conducted in order to investigate the effects of selected probiotic microorganisms in combination with prebiotics, on a growth or activity of proteus mirabilis. in this study the antimicrobial activity of five probiotic lactobacillus spp. (lactobacillus acidophilus(atcc 4356), lactobacillus plantarum (atcc 8014), lactobacillus fermentum (ptcc 1638), lactobacillus casei (ptcc 1608) and lactobacillus rhamnosus (ptcc 1637)) and combination of probiotic and prebiotics (synbiotic) (lactobacillus spp. + five prebiotics : inulin, , trehalose , raffinose, lactulose and riboflavin) tested for their antimicrobial activity against proteus mirabilis (atcc 7002 and ptcc 1076) growth with agar well diffusion (awd) method. results showed that lactobacillus spp. had more antimicrobial activity against proteus spp., followed by inulin, , trehalose , raffinose , lactulose in comparison to basic mrs media (p<0.05) .this increase on antimicrobial activity was strain dependent and can be related to promoting growth and antimicrobial activity of probiotics by prebiotics. so it can be conclude that prebiotic could antimicrobial activity of lactobacillus spp.